<H1>Liquid R-Lipoic Acid -- Relentless Improvement LLC Shopping Cart</H1> <I>2oz (60 Doses) Liquid R-lipoic acid. Stable 10% liquid form of R-Lipoic Acid. Why are you still using alpha-lipoic acid when you can have a stable r-lipoic acid?</I> <P> <IMG SRC="https://store.nexternal.com/relentless/images/K-RALA-10.jpg" ALIGN=right ALT="Liquid R-Lipoic Acid" NAME="Liquid R-Lipoic Acid" BORDER=0 HSPACE=10> K-RALA-10 R-Lipoic Acid 2oz (60 Doses)<BR><BR>Why are you still using alpha-lipoic acid when you can have a stable liquid r-lipoic acid?<BR><BR>GeroNova&#8217;s high bio-availability, stable 10% liquid form of R-Lipoic Acid. Far superior to Alpha-Lipoic Acid or other R-Lipoic Acid in its ability to register meaningful plasma levels after ingestion.<BR><BR>K-RALA-10 r-lipoic acid&#174; solution contains R-lipoic acid (in the form of Potassium-R-Lipoate), potassium bicarbonate, purified water and is preserved with USP vegetable glycerin. <BR><BR>One dropper full delivers the equivalent of 100 mg R-Lipoic Acid and 18-20 mg potassium.<BR>Recommended dose as a nutritional supplement is 1-4 dropper fulls per day together with Acetyl-L-Carnitine. <BR><BR>One dropper full (20 drops) delivers the equivalent of 100 mg R-Lipoic Acid and 18-20 mg potassium.<BR><BR>Add to water, and drink immediately.<BR><BR>R-Lipoic Acid is better absorbed and remains in the plasma longer when taken with fish oils, also available on our site.<BR><BR>Avoid contact with eyes, and if using topically for skin, dilute with 8-10 x water. <BR><BR>K-RALA-10&#8482; contains Potassium-R-Lipoate, potassium bicarbonate, de-ionized water and is preserved with USP grade glycerin. <BR><BR>Human bioavailability studies show oral solutions of R-Lipoate (K-RALA-10&#8482;) provide a plasma level 4.2 times higher than solid dosage forms, have a higher absolute bioavailability (38% vs 26%) and reach maximum plasma concentrations 3.3-4.3 times faster. (1, 2)<BR><BR>Advantages of K-RALA-10&#8482; Over Solid Dosage Forms of R-lipoic acid<BR><BR>Increased stability: no need for refrigeration, stable for at least 3 years at room temperature without polymerization. Solid R-Lipoic Acid is prone to polymerize upon exposure to heat, light and moisture within 6 months. <BR><BR>Increased Solubility: easily dissolved in water, whereas lipoic acid is poorly soluble. <BR><BR>Increased Bioavailability: human pharmacokinetic studies show that the bioavailability of oral solutions is 12% higher than solid dosage forms. (1) <BR><BR>Increased Plasma Levels: human pharmacokinetic studies show that higher plasma levels are reached in a shorter time with oral solutions than from solid dosages of alpha lipoic acid. (1, 2) <BR><BR>Reduced Solvent Residues: due to the low melting point of the lipoic acid crystalline structure, there is a tendency for the product to hold on to high amounts of cyclohexane, ethyl acetate or toluene. The additional processing necessary to make all K-RALA&#174; products removes the residual solvents. <BR><BR>SPECIFICATIONS <BR><BR>K-RALA-10&#8482; is a standard 10% aqueous solution. <BR><BR>Only R-lipoic acid of the highest purity is utilized, after independent analysis confirms the R/S (typical RLA content >99.4%, SLA< 0.6%) and total ALA content. <BR><BR>K-RALA-10&#8482; is processed in US cGMP, FDA approved facilities in the U.S. and meets the highest standards of quality. <BR><BR>GeroNova is the developer and supplier of K-RALA-10&#8482; - Potassium-R-Lipoate solution for dietary supplementation. <BR><BR>References for Lipoic acid Pharmacokinetics <BR><BR>1. Human Pharmacokinetics of Alpha Lipoic acid Chapter 22 in Lipoic Acid in Health and Disease; Hermann R, Niebch G; ed. Fuchs J, Packer L, et al. H Marcel Dekker, Inc New York, Basel, Hong Kong 1997 pp337-360. <BR>2. Dose-proportionality of oral thioctic acid-coincidence of assessments via pooled plasma and individual data. Breithaupt-Grogler K, Niebch G et al. Eur J Pharm Sci. 1999 Apr; 8(1):57-65. <BR>3. Enantioselective pharmacokinetics and bioavailability of different racemic formulations in healthy volunteers. Breithaupt-Grogler K, Niebch G, et al. Eur J Pharm Sci 4 (1996) 167-174<BR><BR>This information is copyright GeroNova Research, Inc. and may not be reproduced in whole or in part in any medium without the express permission of GeroNova Research, Inc. 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