Scientific studies of ISO-E2 ingredients like Acai berries, guarana, yerba maté, mangosteen,
 pomegranate, green tea and essential amino acids.

 * Adhami, V., et al. Molecular targets for Green Tea in prostate cancer prevention. Journal of Nutrition. 133(7):2417S-2424S, 2003.

 * Ascherio, A., et al. Intake of Potassium, Magnesium, Calcium, and Fiber and Risk of Stroke among US Men.

Circulation. 98: 1198 – 1204, 1998.

 * Aviram, M., et al. Pomegranate Juice Consumption for 3 Years by Patients with Carotid Artery Stenosis Reduces Common

Carotid Intima-media Thickness, Blood Pressure, and LDL Clinical Nutrition. 23: 423-433, 2004. Oxidation.

 * Aviram, M., et al. Pomegranate Juice Consumption Reduces Oxidative Stress, Atherogenic Modifications to LDL,

and Platelet Aggregation: Studies in Humans and in Atherosclerotic Apolipoprotein E-deficient Mice. American Journal of

Clinical Nutrition. 71(5): 1062-1076, 2000.

 * Berube-Parent, S., et al. Effects of Encapsulated Green Tea and Guarana Extracts Containing a Mixture of

Epigallocatechin-3-gallate and Caffeine on 24-H Energy Expenditure and Fat Oxidation in Men.

British Journal of Nutrition. 94(3): 432-436, 2005

 * Bettuzzi, S., et al. Chemoprevention of Human Prostate Cancer by Oral Administration of Green Tea Catechins in Volunteers with High-grade Prostate Intraepithelial Neoplasia: a Preliminary Report from a One-year Proof-of-Principle Study. Cancer Research. 66(2): 1234-1240, 2006.

 * Boozer, C., et al. An Herbal Supplement Containing Ma Huang-Guarana for Weight Loss: a Randomized, Double-blind

Trial. International Journal of Obesity. 25(3): 316-324, 2001.

 * Bryan, J., et al. Short-Term Folate, Vitamin B-12 or Vitamin B-6 Supplementation Slightly Affects Memory Performance

But Not Mood in Women of Various Ages. Journal of Nutrition. 132: 1345-1356, 2002.

 * Cao, H., et al. Green Tea Increases Anti-inflammatory Tristetraprolin and Decreases Pro-inflammatory Tumor Necrosis Factor mRNA Levels in Rats. Journal of Inflammation. 4:1, 2007.

 * Carr, A., et al. Vitamin C Protects Against and Reverses Specific Hypochlorous Acid- and Chloramine-dependent

Modifications of Low-density Lipoprotein. Biochemical Journal. 346: 491–499, 2000.

 * Chairungsrilerd, N., et al. Effect of Gamma-mangostin through the Inhibition of 5-Hydroxy-tryptamine2A Receptors

in 5-Fluoro-alpha-methyltryptamine-induced Head Twitch Responses of Mice. British Journal of Pharmacology. 123(5): 855-862,

1998.

 * De Nigris, F., et al. Beneficial Effects of Pomegranate Juice on Oxidation-Sensitive Genes and Endothelial Nitric Oxide Synthase

Activity at Sites of Perturbed Shear Stress. Proceedings of the National Academy of Sciences. 102(13): 4896-4901, 2005.

 * Del Pozo-Insfran, D., et al. Açai (Euterpe oleracea Mart.) Polyphenolics in Their Glycoside and Aglycone Forms Induce

Apoptosis of HL-60 Leukemia Cells. Journal of Agricultural and Food Chemistry. 54(4):1222-1229, 2006.

   * Del Pozo-Insfran, D., et al. Phytochemical Composition and Pigmentation Stability of Açai. Journal of Agricultural and Food Chemistry. 52: 1539-1545, 2004.

 * Doshi, S., et al. Folic Acid Improves Endothelial Function in Coronary Artery Disease via Mechanisms Largely Independent of Homocysteine Lowering.  Circulation. 105(1): 22-26, 2002.

 * Duthie, S., et al. Homocysteine, B vitamin Status, and Cognitive Function in the Elderly. American Journal of Clinical Nutrition. 75(5):908-913, 2002.

 * Ellis, G., et al. Neutrophil Superoxide Anion–generating Capacity, Endothelial Function and Oxidative Stress in Chronic Heart Failure: Effects of Short- and Long-term Vitamin C Therapy. Journal of the American College of Cardiology. 36: 1474 – 1482, 2000.

 * Ellis, J., et al. Response of Vitamin B-6 Deficiency and the Carpal Tunnel Syndrome to Pyridoxine. Proceedings of the National Academy of Sciences. 79: 7494-7498, 1982.

 * Engelhart, M. Dietary Intake of Antioxidants and Risk of Alzheimer Disease. Journal of the American Medical Association. 287:3223-3229, 2002.

 * Friso, S., et al. Low Plasma Vitamin B-6 Concentrations and Modulation of Coronary Artery Disease Risk. American Journal of Clinical Nutrition. 79(6): 992-998, 2004.

 * Harada, N., et al. Taurine Alters Respiratory Gas Exchange and Nutrient Metabolism in Type 2 Diabetic Rats. Obesity Research. 12: 1077-1084, 2004.

 * Hassimotto, N., et al. Antioxidant Activity of Dietary Fruits, Vegetables, and Commercial Frozen Fruit Pulps. Journal of Agricultural and Food Chemistry. 53: 2928-2935, 2005.

 * Hillstrom, R., et al. Vitamin C Inhibits Lipid Oxidation in Human HDL. Journal of Nutrition. 133: 3047-3051, 2003.

 * Ho, C., et al. Garcinone E, a Xanthone Derivative, Has Potent Cytotoxic Effect against Hepatocellular Carcinoma Cell Lines. Planta Medica. 68(11): 975-979, 2002.

 * Hornig, B., et al. Vitamin C Improves Endothelial Function of Conduit Arteries in Patients With Chronic Heart Failure. Circulation. 97: 363 – 368, 1998.

 * Huang, R., et al. N-Acetylcysteine, Vitamin C and Vitamin E Diminish Homocysteine Thiolactone-Induced Apoptosis in Human Promyeloid HL-60 Cells. Journal of Nutrition. 132: 2151-2156, 2002.

 * Huang, T., et al. Pomegranate Flower Improves Cardiac Lipid Metabolism in a Diabetic Rat Model: Role of Lowering Circulating Lipids. British Journal of Pharmacology. 145: 767-774, 2005.

 * Iso, H., et al. The Relationship between Green Tea and Total Caffeine Intake and Risk for Self-reported Type 2 Diabetes among Japanese Adults. Annals of Internal Medicine. 144(8): 554-562, 2006.

 * Jung, H., et al. Antioxidant Xanthones from the Pericarp of Garcinia Mangostana (Mangosteen). Journal of Agricultural and Food Chemistry. 54(6): 2077-2082, 2006.

 * Kang, S., et al. Oxygen Tension Regulates the Stability of Insulin Receptor Substrate (IRS)-1 through Caspase-mediated Cleavage. Journal of Biological Chemistry. (E) Published 2006.

    * Kimura, M., et al. Methylenetetrahydrofolate Reductase C677T Polymorphism, Folic Acid and Riboflavin are Important Determinants of Genome Stability in Cultured Human Lymphocytes. Journal of Nutrition. 134(1):48-56, 2004.

 * Kovacs, E. and Mela, D. Metabolically Active Functional Food Ingredients for Weight Control. Obesity Reviews. 7(1): 59-78, 2006.

  * Lenton, Kevin J., et al. Vitamin C Augments Lymphocyte Glutathione in Subjects with Ascorbate Deficiency. American Journal of Clinical Nutrition. 77: 189-195, 2003

 * Li, C., et al. Green Tea Polyphenols Modulate Insulin Secretion by Inhibiting Glutamate Dehydrogenase. The Journal of Biological Chemistry. 281(15):10214-21, 2006.

 * Lukaski, H. Low Dietary Zinc Decreases Erythrocyte Carbonic Anhydrase Activities and Impairs Cardiorespiratory Function in Men During Exercise. American Journal of Clinical Nutrition. 81: 1045 – 1051, 2005.

 * Malik, A., et al. Pomegranate Fruit Juice for Chemoprevention and Chemotherapy of Prostate Cancer. Proceedings of the National Academy of Sciences. 102(41): 14813-14818, 2005.

 * Marx, F., et al. The Total Oxidant Scavenging Capacity (TOSC) Assay and Its Application to European and Under-utilized Brazilian Fruits. Lebensmittelwissenschaftliches Seminar der DAAD-Alumni, Fortaleza/Brasilien. 11: 21-23, 2005

 * Murase, T., et al.e Green Tea Extract Improves Endurance Capacity and Increases Muscle Lipid Oxidation in Mic. American Journal of Physiology. 288(3): R708-715, 2005.

    * Nakatani, K., et al. Inhibitions of Cyclooxygenase and Prostaglandin E2 Synthesis by -Mangostin, a Xanthone Derivative in Mangosteen, in C6 Rat Glioma Cells. Biochemical Pharmacology. 63: 73-79, 2002.

 * Nakatani, K., et al. -Mangostin Inhibits Inhibitor- B Kinase Activity and Decreases Lipopolysaccharide-Induced Cyclooxygenase-2 Gene Expression in C6 Rat Glioma Cells. Molecular Pharmocology. 66: 667-674, 2004.

    * Nam, S., et al. Ester Bond-containing Tea Polyphenols Potently Inhibit Proteasome Activity In Vitro and In Vivo. Journal of Biological Chemistry. 276(16): 13322-13330, 2001.

  * Neurath, A., et al. Punica Granatum (Pomegranate) Juice Provides an HIV-1 Entry Inhibitor and Candidate Topical Microbicide. BioMed Central Infectious Diseases. 4(41): 1-12, 2004.

    * O’Shea, E. and Lin, K. The Therapeutic Effect of Amino Acids in Prostate Cancer Patients. American Institute for Cancer Research Nutrition and Cancer Prevention. 1-24, 2005.

 * Paddon-Jones, D., et al. Exogenous Amino Acids Stimulate Human Muscle Anabolism without Interfering with the Response to Mixed Meal ingestion. American Journal of Physiology, Endocrinology, and Metabolism. 288(4): E761-E767, 2005.

    * Paleologos M, et al. Cohort Study of Vitamin C Intake and Cognitive Impairment. American Journal of Epidemiology. 148(1):45-50, 1998.

    * Parcell, S. Sulfur in Human Nutrition and Application in Medicine. Alternative Medicine Review. 7(1): 22-44, 2002.

    * Perumal, S., et al. Energy-modulating Vitamins—a New Combinatorial Therapy Prevents Cancer Cachexia in Rat Mammary Carcinoma. British Journal of Medicine. 93(6): 901-909, 2005.

 * Peterman, R. and Goodhart, R. Current Status of Vitamin Therapy in Nervous and Mental Disease. The American Journal of Clinical Nutrition. 2(1): 11-21, 1954.

   * Quadri, P., et al. Homocysteine, Folate, and Vitamin B-12 in Mild Cognitive Impairment, Alzheimer Disease, and Vascular Dementia. American Journal of Clinical Nutrition. 80(1): 114-122, 2004.

    * Ravikumar, A., et al. Tryptophan and Tyrosine Catabolic Pattern in Neuropsychiatric Disorders. Neurology India. 48(3): 231-238, 2000.

 * Ravindranath, M., et al. Epicatechins Purified from Green Tea (Camellia Sinensis) Differentially Suppress Growth of Gender-Dependent Human Cancer Cell Lines. Evidence Based Complementary and Alternative Medicine. 3(2): 237-247, 2006.

 * Riggs, K., et al. Relations of Vitamin B-12, Vitamin B-6, Folate, and Homocysteine to Cognitive Performance in the Normative Aging Study. American Journal of Clinical Nutrition. 63(3):306-314, 1996.

    * Rink, L. and Kirchner, H. Zinc-Altered Immune Function and Cytokine Production. Journal of Nutrition. 130: 1407S-1411S, 2000.

 * Roberts, A., et al. The Effect of an Herbal Supplement Containing Black Tea and Caffeine on Metabolic Parameters in Humans. Alternative Medical Review. 10(4): 321-325, 2005.

    * Rodriques, R., et al. Total Oxidant Scavenging Capacities of Euterpe Oleracea Mart. (Açaí Seeds) and Their Polyphenolic Compounds. Annual Meeting of the Brazilian Society of Chemistry. 29: 19-22, 2006.

 * Ruz, M., et al. Single and Multiple Selenium-Zinc-Iodine Deficiencies Affect Rat Thyroid Metabolism and Ultrastructure. Journal of Nutrition. 129: 174-180, 1999.

    * Salonen, R., et al. Six-Year Effect of Combined Vitamin C and E Supplementation on Atherosclerotic Progression: The Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) Study. Circulation. 107: 947 – 953, 2003.

    * Santillo, V. and Lowe, F. Role of Vitamins, Minerals and Supplements in the Prevention and Management of Prostate Cancer. International Brazilian Journal of Urology. 32(1): 3-14, 2000.

 * Sato, A., et al. ?-Mangostin Induces Ca2+-ATPase-Dependent Apoptosis via Mitochondrial Pathway in PC12 Cells. Journal of Pharmacology. 95: 33-40, 2004.

 * Schauss, A., et al. Antioxidant Capacity and Other Bioactivities of the Freeze-dried Amazonian Palm Berry, Euterpe Oleraceae Mart. (Acai). Journal of Agricultural and Food Chemistry. 54(22): 8604-10, 2006.

 * Senthilkumar, R., et al. Glycine Modulates Hepatic Lipid Accumulation in Alcohol-induced Liver Injury. Polish Academy of Sciences. 55: 603-611, 2003.

    * Shaneyfelt, M., et al. Natural Products that Reduce Rotavirus Infectivity Identified by a Cell-based Moderate-throughput Screening Assay. Virology Journal. 3:68, 2006.

 * Simon, J., et al. Relation of Serum Ascorbic Acid to Mortality among US Adults. Journal of the American College of Nutrition. 20: 255-263, 2001.

 * Solzbach, U., et al. Vitamin C Improves Endothelial Dysfunction of Epicardial Coronary Arteries in Hypertensive Patients. Circulation. 96: 1513 – 1519, 1997.

 * Suksamrarn, S., et al. Antimycobacterial Activity of Prenylated Xanthones from the Fruits of Garcinia Mangostana. Chemical & Pharmaceutical Bulletin. 51(7):857-859, 2003.

 * Szyndler, J., et al. Effect of Kindled Seizures on Rat Behavior in Water Morris Maze Test and Amino Acid Concentrations in Brain Structures. Pharmacological Reports. 58: 75-82, 2006.

    * Tang, X. and Shay, N. Zinc Has an Insulin-Like Effect on Glucose Transport Mediated by Phosphoinositol-3-Kinase and Akt in 3T3-L1 Fibroblasts and Adipocytes. Journal of Nutrition. 131: 1414-1420. 2001.

 * Title, L., et al. Effect of Folic Acid and Antioxidant Vitamins on Endothelial Dysfunction in Patients with Coronary Artery Disease. Journal of the American College of Cardiology. 36: 758-765, 2000.

    * Tsuboyama-Kasaoka, N., et al. Taurine (2-aminoethanesulfonic acid) Deficiency Creates a Vicious Circle Promoting Obesity. Endocrinology. 147(7): 3276-3284, 2006.

 * Ukkola, O., et al. Protein Tyrosine Phosphatase 1B Variant Associated with Fat Distribution and Insulin Metabolism. Obesity Research. 13: 829-834, 2005.

 * Voravuthikunchai, S. and Kitpipit, L. Activity of Medicinal Plant Extracts against Hospital Isolates of Methicillin-resistant Staphylococcus Aureus. Clinical Microbiology and Infection. 11(6): 510-512, 2005.

 * Warburton, D., et al. An Evaluation of a Caffeinated Taurine Drink on Mood, Memory and Information Processing in Healthy Volunteers without Caffeine Abstinence. Psychopharmacology. 158: 322-328, 2001.

 * Werbach, M. Nutritional Strategies for Treating Chronic Fatigue Syndrome. Alternative Medicine Review. 5(2):93-108, 2000.

    * Westerterp- Plantenga, M., et al. Body Weight Loss and Weight Maintenance in Relation to Habitual Caffeine Intake and Green Tea Supplementation. Obesity Research. 13: 1195- 1204, 2005.

 * Won, S., et al. Catechins Inhibit Angiotensin II-induced Vascular Smooth Muscle Cell Proliferation via Mitogen-activated Protein Kinase Pathway. Experimental and Molecular Medicine. 38(5): 525-534, 2006.